Volumetry versus linear diameter lung nodule measurement; an ultra-low-dose CT Lung Cancer Screening Study

Backgraund: the Dutch-Belgium randomised lung cancer screening trial (NELSON) used a volume-based protocol, and was able to significantly reduce prevalence of false positive results (2.1%). The aim this study compare performance manual linear diameter semi-automated volumetric nodule measurement, in MLCS ultra-LDCT pilot study.
 Aims: volume measurements Russian low-dose CT (LDCT) program.
 Materials methods: all two-hundred ninety-three individuals with at least 4 mm on their baseline Moscow between February 2017 2018, without verified diagnosis until 2020, were included. Radiation dose selected individually did not exceed one mSv. All scans assessed by three blinded readers measure maximum minimum transversal extrapolated volume. As reference value size we took average obtained from expert measurements. A false-positive defined as 6mm/100mm3. false-negative 6mm/100mm3.
 Results: 293 patients included (166 men, mean age 64.6 5.3years). 199 nodules 6mm/100mm3 94 For measurements; 32 [10.9%; FP 4, FN 28], 29 [9.9%; 17 FP, 12 FN], 30 [10.2%; 6 24 FN] discrepancies reported reader 1, 2 3 respectively. 92 [65.5%; 107 85 146 [49.8%; 58 88 102 [34.8%; 23 79 respectively.
 Conclusions: Use volumetry strongly reduces number compared measurements, an program.